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ea0019p272 | Pituitary | SFEBES2009

A single early morning serum cortisol in the early post operative period following transphenoidal surgery for pituitary tumours accurately predicts hypothalamo–pituitary–adrenal function

Jayasena CN , Gadhvi KA , Gohel B , Martin NM , Mendoza N , Meeran K , Dhillo WS

Background: Secondary adrenal insufficiency is a common complication of transsphenoidal hypophysectomy (TSS) for pituitary adenoma. It is therefore imperative to rapidly and accurately identify patients requiring glucocorticoid replacement, thus minimising risks of adrenal insufficiency or unnecessary glucocorticoid exposure. The gold-standard test of HPA axis reserve, the insulin tolerance test (ITT), cannot be performed safely until after post-operative recovery. Nine am cor...

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ea0019oc4 | Young Endocrinologist prize session | SFEBES2009

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

Jayasena CN , Chaudhri OB , Nijher GK , Murphy KG , Ranger A , Lim A , Patel D , Mehta A , Todd C , Ramachandran R , Salem V , Stamp GW , Donaldson M , Ghatei MA , Bloom SR , Dhillo WS

Background: Kisspeptin is a critical regulator of normal reproductive function. In humans inactivating mutations of the kisspeptin receptor GPR54 cause hypogonadotrophic hypogonadism and pubertal failure. Activating mutations of GPR54 cause precocious puberty. Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. In rodent models of HA hypothalamic KISS1 expressi...

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Endocrine Abstracts

A single early morning serum cortisol in the early post operative period following transphenoidal surgery for pituitary tumours accurately predicts hypothalamo–pituitary–adrenal function

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

BiosciAbstracts